This article is devoted to discussion of the philosophical aspects of the problems associated with the creation of a strong artificial intelligence. It is noted that even taking into account the fact that the study of the brain and consciousness are represented by separate areas, such as cognitive neuroscience and philosophy of consciousness, there are a number of problems of an ontological nature, which indicate that research in the field of creating systems with artificial intelligence, although actively developing, is rather (...) related to its weak definition and does not provide prerequisites for confidence in the possibility of creating a strong artificial intelligence. (shrink)

The subject of this study is a set of alleged contradictions in the development of artificial intelligence, pursued in order to achieve their overcoming. Philosophical anthropology contains the potential to analyze complex interactions, to articulate the problems that arise between artificial intelligence and humans. The philosophical and anthropological analysis of artificial intelligence is aimed at understanding this human phenomenon, human presence and its experience. The article is an attempt to identify and outline the trajectories for the possible resolution of the (...) contradiction in the development of artificial intelligence, the analysis of the parameters proposed by philosophical anthropology to solve their problems in the modern socio-cultural situation. The relevance of the proposed problem arises in the fact that artificial intelligence qualitatively changes the existence of a person, and in philosophical anthropology there is a potential to outline the prospects for the development of artificial intelligence, while preserving the languid human in a person. To study this perspective is very important in society. The novelty of the topic raised in the article is the analysis of solving the problems of artificial intelligence from the standpoint of philosophical anthropology, in the articulation of contradictions in the development of artificial intelligence, in the search for solutions to overcome these contradictions. Philosophical anthropology provides tools for a balanced decision on the development of artificial intelligence, the degree of its impact on human existence. (shrink)

The purpose of the study is to reveal the main actions of the major central banks during the COVID - 19 pandemic and their main impact on the world stock markets. The scientific novelty consists in identifying the key results of the impact of the pandemic in general and the restrictive measures of national governments, in particular, on the dynamics of the state of the stock markets of the world, namely, the level of decline in the main stock indexes of (...) the S &P 500, Dow Jones and NASDAQ. The measures taken by the central banks of the United States, Japan, England and other developed and developing countries of the world to provide financial assistance to commercial banks and other financial organizations related to the purchase of government bonds at a "zero" rate, targeting the yield of government bonds, reducing key rates and other measures are summarized. It is indicated that the influx of new private investors provided a great help to the stock market, for which many Central Banks introduced special programs and preferences. As a result, the main measures taken by the Central Bank of the Russian Federation to stabilize the financial situation in the country and the domestic stock market, in particular, are summarized. (shrink)

This book explores the major differences between the kinds of risk encountered in different sectors of industry - production and services - and identifies the main features of accidents within different industries. Because of these differences, unique risk-mitigation measures will need to be implemented in one industry that cannot be implemented in another, leading to large managerial differences between these broad economic sectors. Based on the analysis of more than 500 disasters, accidents and incidents - around 230 cases from the (...) production sector and around 280 cases from the service sector - the authors compare the risk response actions appropriate within different sectors, and establish when and how it is possible to generalize the experience of dealing with risks in any given industry to a wider field of economic activity. This book is mainly intended for executives, strategists, senior risk managers of enterprise-wide organizations and risk management experts engaged in academic or consulting work. By setting out clearly the sector differences in risk management, the authors aim to improve the practice of general risk assessment with regard to identifying and prioritizing risks, and of risk control with regard to planning appropriate mitigation measures. (shrink)

Journal Name: Apeiron Issue: Ahead of print.

The article develops the idea of forming postcapitalist social relations as a social revolution of an individual, which consists in the fact that popularity becomes a key advantage, the “possession” of which is a desired goal and a significant resource of political influence. At the same time, it is shown that this process leads to forming a new dominant stratum — personalities (“people with personality”): celebrities, popular bloggers, social media influencers, micro- and nanosignature. It is substantiated that the personaliat domination (...) is a consequence of contradictory social relations between the new aristocracy represented by the representatives of the personaliat and many people who do not “possess” a popular personality - the impersonaliat (“extra people”, “lower” precariat, those who turn out to be outsiders in the world of social platforms). This contradiction is associated with the rooting of a celebrity’s culture, which encourages a lot of people to fight for popularity and focus on finding advantageous differences from others in the process of self-realization. However, this struggle in the end for the overwhelming majority turns into an increase in creative competition and subtraction. Various new forms of subtraction that appear in situations of widespread self-realization are revealed. Accordingly, arguments are given in favor of the fact that in the context of the “personality revolution”, the truly left will be rather an alternative that will call into question the ways of solving social problems formulated by popular personalities. In other words, it will be possible to oppose the total pursuit of popularity with the projects of society, in which the person is relied not as someone who rises above the others, but as an involved person who values life in harmony with others higher than his own “I”. (shrink)

The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, (...) together with the implications of their association for the structure of the chromatin fibre. (shrink)

A conception of an information system has been introduced by Pawlak. The study has been continued in works of Pawlak and Orlowska and in works of Vakarelov. They had proposed some basic relations and had constructed a formal system of a modal logic that describes the relations and some of their Boolean combinations. Our work is devoted to a generalization of this approach. A class of relation systems and a complete calculus construction method for these systems are proposed. As a (...) corollary of our main result, our paper contains a solution of a Vakarelov's problem: how to construct a formal system that describes all the Boolean combinations of the basic relations. (shrink)

This article deals with the question of the interrelation between two papers, both called, in short, “Onomatodoxy”, dedicated to the doctrine of Name-glorification (Imiaslavie, Onomatodoxy), both of which were created in line with the Neo-Patristic movement in the Russian philosophy of the Silver Age. One of these papers is by Alexei Losev and the other by Pavel Florensky. In my opinion, there are sufficient grounds to state that Losev’s “Onomatodoxy” was written either after Florensky created his own “Onomatodoxy”, i.e., after (...) November 1922, or, at the earliest, after Florensky started to give clandestine lectures about Onomatodoxy in Moscow (where Losev lived), i.e., not earlier than spring 1921. Therefore, Losev’s article “Onomatodoxy” could have been intended for the religious-philosophical collection of articles planned for publishing by Yaschenko in 1922 in Berlin. (shrink)

Introduction. One of the drivers of the Russian regions’ development is traditionally considered to be local universities and the scientific activity development, in particular. However, such a belief is usually based on speculative conclusions and is not subjected to detailed empirical testing. The purpose of the study is to assess the relationship between the development of science in universities in Russian regions and indicators of regional development according to 2017—18 data. Methods. The authors use methods of generalization, grouping, assessment of (...) indicators of central tendency and variations, as well as methods of correlation analysis. The study is based on the data from regional statistics presented on the official website of Russian Statistics Agency, as well as data from monitoring the universities effectiveness, commissioned by the Ministry of Science and Higher Education of the Russian Federation. Scientific novelty of the research. For the first time, the authors present an empirical analysis of the relationship between indicators of socioeconomic development of Russian regions and indicators of scientific activity in universities in the region. The study is characterized by using a sample of homogeneous regions. The sample excluded regions that did not have significant scientific results, as well as regions that are leaders in economic development. As a result, a “core” of 57 Russian regions with similar characteristics of both economic development and the results of scientific activity was investigated. This increased the practical significance of the conclusions and their reliability. Results. As a result of the study, it was found out that there is a statistically significant relationship between all indicators of regional development and science in universities. However, a deeper analysis made it possible to establish that this relationship is indirect. In some cases, we can talk about the opposite influence - regional development on scientific results in universities. Conclusions. It was found that the indicators used in the public administration system for assessing the effectiveness and efficiency of scientific activity are not key in terms of their impact on regional development. It was revealed that publications in leading world databases and in the Russian Science Citation Index (RSCI) are equally related to regional development. It has been determined that in a number of cases, within the considered sample, it is possible to distinguish two groups of regions with a different nature of the relationship between regional development and science in universities. (shrink)

Ambiguity affects decisions of people who exhibit a distaste of and require a premium for dealing with it. Do ambiguity-neutral subjects completely disregard ambiguity and react to any vague news? Online vending platforms often attempt to affect buyer’s decisions by messages like “20 people are looking at this item right now” or “The average score based on 567 reviews is 7.9/10”. We augment the two-color Ellsberg experiment with similarly worded signals about the unknown probability of success. All decision-makers, including ambiguity-neutral, (...) recognize and account for ambiguity; ambiguity-neutral subjects are less likely to respond to vague signals. The difference between decisions of ambiguity-neutral and non-neutral subjects vanishes for high precision signals; still less than 60% subjects choose the ambiguous urn, even for high communicated probabilities of success. We conjecture participants may discard information, if they see no contradiction between it and their prior beliefs, hence the latter are not updated. Higher confidence makes subjects more likely to discard the news, and empirically ambiguity-neutral subjects appear more confident than those ambiguity-averse. (shrink)

Comparative study between Tibetan Bon and Buryatian Bø religion of ancient Shamanic traditions.

Introduction. The human world is presented as an integrity — an organic unity of many inter- connected and interdependent centers (parts, sides, elements): natural and cultural, natural and artificial, animate and inanimate. When any center dominates over others (for example, technical and technological) and / or attempts to realize its claim to the status of a whole, the agreed and optimal ra- tio in the coexistence and synergistic development of all centers, and, consequently, of the whole, is violated. There arises (...) an ecosystem problem. The purpose of the study is to present and analyze the techno-technologized world in the context of current philosophical and scientific methodologi- cal principles: polycentricity, complexity, network- centricity, and ecosystem; to designate their theoretical and practical significance, interdepend- ence; to substantiate the principle of ecosystems as more general and fundamental and to present its effectiveness in preserving the integrity of man, his world and the full value of human being-in-the- world. Methods. The author uses methods of dialectics, synergetics and systemic approach in the philo- sophical understanding of the specifics of the modern techno-technological world and a person’s existence in it. The author also uses the methods of extrapolation and interpretation, the ideas of B. Latour’s actor-network theory, and ecosystem approach. Scientific novelty of the research. The author projects the key attitudes and concepts of the actual conceptual and paradigm principles on the techno-technological world, and formulates the main advantages and disadvantages. The author substantially justifies that the principle of ecosys- tem is the most effective in solving the problem of preserving and reproducing the integrity of the human world, the person himself and his being. Results. The author carries out theoretical and methodological analysis of the techno-technolo- gized world and a person’s existence in it. It has been determined that when solving the problem of preserving and reproducing the integrity of a person and his world, the principle of ecosystems is the most effective and preferable. The ecosystem principle implies the synergistic unity of all centers of human existence, their interdependence and interconnection, ensures the priority of the whole for the benefit of each center, expressed in mutual strengthening and expansion of their potential. Conclusions. The author comes to the conclusion that the application of relevant paradigm principles in studying and analyzing the techno-technological world will make it possible to obtain a more mul- tidimensional and accurate interpretation of the ways and means of achieving a full-fledged human being, with a focus on preserving his identity, origi- nality, subjectivity and integrity. (shrink)

We explore a possibility of generalization of classical truth values by distinguishing between their ontological and epistemic aspects and combining these aspects within a joint semantical framework. The outcome is four generalized classical truth values implemented by Cartesian product of two sets of classical truth values, where each generalized value comprises both ontological and epistemic components. This allows one to define two unary twin connectives that can be called “semi-classical negations”. Each of these negations deals only with one of the (...) above mentioned components, and they may be of use for a logical reconstruction of argumentative reasoning. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN 3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is (...) asserted, d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT 4 . Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a –order (truth order) and d –order (falsity order) coincide with first-degree entailment. Finally logic with two kinds of operations ( a –connectives and d –connectives) and consequence relation defined via a –ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

I detect a specific attitude to Byzantium (“the Byzantine Enlightenment”) in Ivan Kireevsky’ Slavophile article “On the Character of Enlightenment in Europe” (1852). I qualify this attitude as Byzantinocentrism. I take that as a focal point and, against this background, consider the image of Byzantium in Kireevsky and some thinkers of his social circle. It allows me to trace the most important lines of attitudes to Byzantium in the Russian historiosophical literature and opinion journalism of the nineteenth century. I detect (...) two opposite lines in perceiving Byzantium in Kireevsky’s early social circle: the anti- and pro-Byzantine ones. The first line goes back to an anti-Byzantine message, characteristic of the epoch of Enlightenment. It found its manifestation in G. W. F. Hegel’s Lectures on the Philosophy of History. I point to the traces of the implicit polemics with Hegel’s anti-byzantinism in Kireevsky and identify the context of these polemics in Arist Kunick. As well, I outline how these lines worked in Pyotr Chaadaev and Alexander Pushkin. Then I distinguish between how the image of Byzantium was presented, first, in Kireevsky’s earlier Slavophile article “On the Character of Enlightenment in Europe” and, second, in his last article “On the Necessity and Possibility of the new Foundations for Philosophy” (1856). In the latter article, which sees Byzantium as bipolar, I find another view on Byzantium. I suggest that this view on Byzantium as a bipolar entity goes back to Alexey Khomyakov’s Semiramis. My point is that this difference in the views on Byzantium is paradigmatic and it reflects a division that was present in the Russian Slavophile-conservative milieu of that time. I suggest that this division stands behind another division within the same milieu, which was politically oriented, the one in relation to the Greek-Bulgarian ecclesiastical question. I analyze how both monopolar (Byzantinocentric) and bipolar views on Byzantium were reflected in the Greek-Bulgarian question as it was considered by Alexey Khomyakov and Terty Filippov. I find a context for developing Kireevsky’s attitude towards Byzantium in François Guizot’s historiosophic scheme as well. (shrink)

In this paper we continue the study of Girard's Linear Logic and introduce a new Linear Logic with modalities. Our logic describes not only the consumption, but also the presence of resources. We introduce a new semantics and a new calculus for this logic. In contrast to the results of Lincoln [7] and Kanovich [4] about the NP-completeness of the problem of the construction of a proof for a given sequent in the multiplicative fragment of Girard's Linear Logic, we present (...) here a non-exponential algorithm to construct a proof for a given sequent and a given point of a given model in our Linear Logic. (shrink)

Introduction. A human and the world are an organically connected part and whole, they are always a single World, and therefore they can only evolve together, in one direction. The human world consists of many interconnected and interdepend- ent parts. If any one of the parts (for example, technology) begins to dominate and claim the sta- tus of the whole, then the problem of violating the optimal ratio in the coexistence and co-evolutionary development of each of the parts, and hence (...) the whole itself, becomes aggravated. Hence, the eco-humanistic problem arises. The purpose of the work is to present the content and substantiate the theoretical and practical significance of eco-humanism as a new humanitar- ian knowledge and methodology for understanding the specifics of the relationship “man — technical and-technological world”. Methods. The author uses the methods of dia- lectics, systemic and synergetic approaches, the project (projective) method, which is implemented in the design and development of a new philo- sophical and scientific discipline of eco-humanism, and ideas of co-evolution. Scientific novelty of the research. The author determines basic foundations of eco-humanism as a new type of humanitarian knowledge; formulates and meaningfully substan- tiates the main principles of eco-humanism as a methodological setting for the ecologization of a person and the world: optimality, coordination and dominance of the whole (integrity) in relation to its parts. Results. Eco-humanistics is defined as a new type of knowledge about a person and a specific setting of his thinking and practical activities, focused on finding ways and means to achieve op- timality in relation to various aspects (for example, technical and anthropological) in a person’s being to ensure the possibility of their fruitful existence, to preserve and reproduce a person (as a unique integrity) and his world (as a universal integrity), in their interconnected and interdependent unity. Conclusions. The author of the article comes to the conclusion that the theoretical development of eco-humanistics will make it possible to study and analyze the phenomena of modern culture in a more multifaceted way, to get a more accurate interpretation of the ways of human existence and eco-cultural practices that provide the effect of the state of the “ecosystem” in situations of any intense socio-cultural transformations. (shrink)

In their useful logic for a computer network Shramko and Wansing generalize initial values of Belnap’s 4-valued logic to the set 16 to be the power-set of Belnap’s 4. This generalization results in a very specific algebraic structure — the trilattice SIXTEEN3 with three orderings: information, truth and falsity. In this paper, a slightly different way of generalization is presented. As a base for further generalization a set 3 is chosen, where initial values are a — incoming data is asserted, (...) d — incoming data is denied, and u — incoming data is neither asserted nor denied, that corresponds to the answer “don’t know”. In so doing, the power-set of 3, that is the set 8 is considered. It turns out that there are not three but four orderings naturally defined on the set 8 that form the tetralattice EIGHT4. Besides three ordering relations mentioned above it is an extra uncertainty ordering. Quite predictably, the logics generated by a–order and d–order coincide with first-degree entailment. Finally logic with two kinds of operations and consequence relation defined via a–ordering is considered. An adequate axiomatization for this logic is proposed. (shrink)

In this paper we introduce a new type of nets with bounded types of distributed resources . Linear Logic to describe the behaviour of BR-nets is defined. It is based on Girard's Linear Logic but captures not only consumption of resources but their presence as well. Theorem of soundness and completeness of the proposed axiomatization is proved and the complexity of the provability problem is established for the general case and some particular ones.

The fact that modern artists are turning toward science and the latest technologies—robotics, information technology, biomedicine—forces us to reformulate our concept of art. One need only imagine...

In lieu of an abstract, here is a brief excerpt of the content:Dmitry Khanin THE POSTMODERN POSTURE Postmodernists—the sectarians ofour day—proclaim that the old kingdom of historical narrative and historical subject has perished, and is now being replaced by a new one of ahistorical discourses and ahistorical characters. According to these prophets, "history" is anyway just changes in ways of talking about history. Anyone who does not agree with the ahistoricity of the postmodern world oudook may be accused—and tried (...) on the spot—of defending the cause of the totalitarian Reason against the most liberating movement of today. This postmodernist abuse of history is paradoxical, since the very notion of history coming to its end and giving way to the ahistorical kingdom of freedom and merry debauchery is itself a very old idea, even a mythological one. The description ofhistory as marching toward its own demise relies on a whole tradition which portrays history as a drama. Aristode's conception of tragedy as a sequence of actions culminating in a dénouement has no doubt shaped this view of historical process. Christian and other religious millenarians have announced the end of history already many times. Yet another notorious instance of such eschatological daydreaming is the futurology of Karl Marx, who envisaged the kingdom of communism as occupying this same ahistorical space. A rather obsolete idea, perhaps, but it seems still to attract postmodernists, though they give it a characteristic twist, since they sincerely believe theory, discourse, écriture (i.e., theoretico-symbolical activity) are much more important than any actual historical contentprocesses and events. One of the most notable spokesmen for this approach is Arthur Danto, who insists that world history evolved in a good Hegelian manner until the theorists came to understand that history depends on their Philosophy and Literature, © 1990, 14: 239-247 240Philosophy and Literature texts much more than theorists themselves depend on historical processes and events.1 Many theoreticians working in an otherwise Marxist tradition similarly are glad to assert with FredricJameson that we must say farewell to Marx's positivistic illusion that history is driven by laws disguised as economic forces.2 In the epoch of "late capitalism," says Jameson, consumption gains the upper hand over production and becomes the mainspring of history. Of course, in light of recent doings in Europe I am tempted to ask if we owe it to postmodernists—and their ahistorical, inconsistent, and generally confounding claims about history lying in ruins—that the Berlin Wall actually is in ruins and Vaclav Havel is president of Czechoslovakia. Even more daring theorists may now declare an era of "very late capitalism." Here it will not be merely the mass media that act transformatively on society (as McLuhan claimed), but rather consumer goods themselves, like state-of-the-art washing machines or French perfumes, which create a new aura of intellectual discourse. TL· Postmodern Scene: Excremental Culture and Hyper-AesÜietics, a book by two Canadian authors, Arthur Kroker and David Cook, promotes such a sea change in the theoretical landscape and along the way presents a joyous recapitulation ofthe latest fads in postmodern thinking. The new apostolic generation ofpostmodern critics seems to enjoy the beautiful new things that can be bought for bucks, worrying at the same time that bucks may be losing some of their purchasing power. Like Hari-Krishnas dancing in the street they luckily possess a sort of happy consciousness which also recalls their puritanical great grandfathers who regarded profligacy as the greatest sin and much preferred saving to spending. In what follows I want to draw a portrait of this new postmodern posture. A few main assumptions underlie Kroker's and Cook's wake for postmodernism, which, in its peculiar genre of philosophic obituary, epitomizes and thus prepares for future oblivion views which were exceedingly popular in the preceding decade. First of all, the authors adopt Baudrillard's equation of Marx and Nietzsche: "Marx and Nietzsche shared a deep and common affinity in meditating upon historical (Christian) and materialistic (capitalist) expressions ofthewill ofpower."3 From Baudrillard's perspective Marx appears as a pathetic romantic who tried to defend the "referential illusion" by renaturalizing concrete labor even though its entirely abstract character was brilliandy revealed in Das Kapital. Baudrillard... (shrink)

The purpose of the study is to investigate the features of the algorithm for forming the stock portfolio of investors using the theory of fuzzy sets, taking into account a priori uncertain input information and market dynamics. The scientific novelty of the article lies in the application of a relatively new fuzzy-multiple apparatus and the theory of fuzzy sets to the formation of the stock portfolio of investors. From a practical point of view, the proposed fuzzy model makes it possible (...) to predict not only the structure and expected return of a portfolio of securities, similarly to the application of the classical portfolio theory, but also to obtain the values of the lower and upper boundaries of the return on securities, which will allow the investor to form a more complete picture of the structure of the portfolio in the future. As a result, it was found that the use of classical statistical approaches for the formation of a stock portfolio of investors will not allow obtaining a reliable and accurate result, since traditional methods do not take into account the uncertainty factors of events in the stock market. To level information asymmetry and eliminate risks of uncertainty, it is advisable to apply the theory of fuzzy logic. (shrink)

The authors try to show that even Wittgensteinian definition of concept is not always sufficient to analyze what really happens in science. As a result, in addition to “concept” we propose “conception” as a new promising tool for philosophy of science. We provide a brief historical analysis of this term and reveal two main interpretations of “conception” in philosophy and scientific disciplines. In accordance with the first view, conception appears as either a “twin” of the concept, or a pair entity (...) to the concept. According to the second view, conception is a kind of “strange concept” that exists among “normal” concepts. Since conception is understood differently in sciences and philosophical systems, it is not possible to give a generalized definition of conception. That is, it is impossible to formulate this definition, so to speak, inductively. Moreover, even if it was possible, such a definition would not necessarily have to be automatically accepted by philosophy of science. That is why the introduction of a concept of conception was carried out through the analysis of a global process associated with the return of metaphysics to science. We define conception as a semantic construction denoting the unknown (and, possibly, fundamentally unknowable) and ensuring the possibility of working with this unknown (unknowable). By virtue of the way conception was introduced (conception is not a “generalization” of the interpretations available in specific sciences) many conceptions that are considered as conception in specific sciences turn out to not to be conceptions within this definition. Thus, the article interprets conception as a new possible tool of philosophy of science, which is aimed at understanding how specific sciences develop. (shrink)

A groundbreaking, revisionist account of the importance of the history of philosophy to intellectual change - scientific, philosophical and religious - in seventeenth-century England.

SummaryHistorians of science have neglected early modern natural philosophers' varied attitudes to the history of philosophy, often preferring to use loose labels such as ‘Epicureanism’ to describe the survival of ancient doctrines. This is methodologically inappropriate: reifying such philosophical movements tells us little about the complex ways in which early modern natural philosophers approached the history of their own discipline. As this article shows, a central figure of early modern natural philosophy, Robert Boyle, invested great intellectual energy into his depiction (...) of the history of philosophy. Boyle's historical worldview was mediated through an array of textual traditions: classical, patristic, humanist and contemporary. Drawing extensively on his manuscript notes, this is examined for three topics. First, from his turn to natural philosophy in the late 1640s, Boyle combined a sceptical attitude towards philosophy's potential – stemming from humanist historicisations of the ‘speculative’ heritage of Greek philosophy – with a belief in natural philosophy's efficacy as a spiritual exercise, as performed by ancient ‘priests of nature’. Second, Boyle's attitude to the history of matter theory was far more complex than any simple comparison with ‘ancient atomism’ can convey. Unlike many of his contemporaries, Boyle held Epicurus to be a speculative and reductionist philosopher, leading him to posit a different lineage for a non-reductionist corpuscularianism which depended on exploitation of non-standard historiographical traditions. Appreciating this allows us to make an intervention in the ongoing debate about the relationship between corpuscularianism, chymistry and experiment in Boyle's philosophy. Third, Boyle's historicisation of supposedly anthropomorphic philosophies in his famous Free Enquiry exploited recent theological historiography, most importantly Samuel Parker's combination of the history of idolatry with the history of Greek philosophy, which itself relied on developments in continental sacred history. It was this historicisation, rather than any philosophical realities, which led to the positing of the mechanical philosophy as more compatible than Aristotelianism with Christian doctrine. (shrink)

The transcription factor Nrf2 is the master regulator of cellular stress response, facilitating the expression of cytoprotective genes, including those responsible for drug detoxification, immunomodulation, and iron metabolism. FDA‐approved Nrf2 activators, Tecfidera and Skyclarys for patients with multiple sclerosis and Friedreich's ataxia, respectively, are non‐specific alkylating agents exerting side effects. Nrf2 is under feedback regulation through its target gene, transcriptional repressor Bach1. Specifically, in Parkinson's disease and other neurodegenerative diseases with Bach1 dysregulation, excessive Bach1 accumulation interferes with Nrf2 activation. Bach1 (...) is a heme sensor protein, which, upon heme binding, is targeted for proteasomal degradation, relieving the repression of Nrf2 target genes. Ideally, a combination of Nrf2 stabilization and Bach1 inhibition is necessary to achieve the full therapeutic benefits of Nrf2 activation. Here, we discuss recent advances and future perspectives in developing small molecule inhibitors of Bach1, highlighting the significance of the Bach1/Nrf2 signaling pathway as a promising neurotherapeutic strategy. (shrink)

It is now clear that two prominent nuclear domains, interchromatin granule clusters (IGCs) and Cajal bodies (CBs), contribute to the highly ordered organization of the extrachromosomal space of the cell nucleus. These functional domains represent structurally stable but highly dynamic nuclear organelles enriched in factors that are required for different nuclear activities, especially RNA biogenesis. IGCs are considered to be the main sites for storage, assembly, and/or recycling of the essential spliceosome components. CBs are involved in the biogenesis of several (...) classes of small RNPs as well as the modification of newly assembled small nuclear RNA. We have summarized data on the molecular composition, structure, and functional roles of IGCs and CBs in the nuclei of mammalian somatic cells and oocytes of some animals with a special focus on insects. We have focused on similarities and differences between the IGCs and CBs of oocytes and the well‐studied CBs and IGCs of cultured mammalian somatic cells. We have shown the heterogeneous character of oocyte IGCs and CBs, both in structure and molecular content. We have also demonstrated the unique capacity of oocytes to form close structural interactions between IGC and CB components. We proposed to consider these joint structures as integrated entities, sharing the features of both IGCs and CBs. (shrink)

The outburst of antiracist protests in the USA in 2020 demonstrates how deeply this society’s present-day problems are rooted in its past. From this perspective, a study of the cultural memory of the time of the Civil War and the abolition of slavery, the key moment in the contemporary American nation formation, is especially relevant and important. The cultural frontier between the North and the South that had appeared as an outcome of differences in US history has not disappeared up (...) to now. By example of the complexity and inconsistency of the historical memory of the Civil War, slavery, and its abolition in the USA manifested in their visual representations, the article documents how through collective memory, history does not just invade modernity but is present in it, particularly in the form of memorials, monuments, museum expositions, and therefore determines the nation’s modernity to a large degree. (shrink)

A structured collection of tools for engineering resilience and a research approach to improve the resilience of a power grid are described in this paper. The collection is organized by a two-dimensional array formed from typologies of power grid components and business processes. These two dimensions provide physical and operational outlooks, respectively, for a power grid. The approach for resilience research is based on building a simulation model of a power grid which utilizes a resilience assessment equation to assess baseline (...) resilience to a hazards’ profile, then iteratively selects a subset of tools from the collection, and introduces these as interventions in the power grid simulation model. Calculating the difference in resilience associated with each subset supports multicriteria decision-making to find the most convenient subset of interventions for a power grid and hazards’ profile. Resilience is an emergent quality of a power grid system, and therefore resilience research and interventions must be system-driven. This paper outlines further research required prior to the practical application of this approach. (shrink)

In this paper, we obtain axiom systems, bases of identities and quasi-identities for classes of algebras of binary relations with a conjunctive operation, i.e., an operation that can be defined by a logical formula containing only conjunctions. The result of applying such an operation to two binary relations is the Cartesian product of their reflexive projections. Our consideration of these classes leads to the concept of quasi-semilattices as a natural generalization of the notion of semilattices.